Brand name: Effient Dosage form: oral tablet (10 mg; 5 mg) Drug class: Platelet aggregation inhibitors. Medically reviewed by Drugs on May 30, 2024. Written by Cerner Multum. Uses; ... Swallow the tablet whole and do not crush, chew, or break it. Because prasugrel keeps your blood from clotting, prasugrel can also make it easier for you to ...

Study design: COMPARE CRUSH (NCT03296540) is a randomized trial in a regionally organized ambulance care setting evaluating the efficacy and safety of pre-hospital loading dose with prasugrel crushed tablets versus integral tablets in approximately 674 patients presenting with STEMI planned for primary PCI. The independent primary endpoints are ...

Clopidogrel (Plavix) and prasugrel (Effient) are both P2Y12 inhibitors used to prevent heart attacks and strokes, but they have some key differences. Clopidogrel is used for people with a history of heart attack, stroke, or peripheral artery disease, while prasugrel is specifically for those who have had a stent placed after a heart attack.

Effient: 5 mg, 10 mg. Generic: 5 mg, 10 mg. Pharmacology Mechanism of Action. Prasugrel, an inhibitor of platelet activation and aggregation, is a prodrug that is metabolized to both active (R-138727) and inactive metabolites.

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Chest X-ray; Echocardiogram; Angiogram; Cardiac computerized tomography scan or magnetic resonance imaging; Types and Prognosis of Heart Attack. Heart attacks are divided into types based on severity.

Swallow the tablet whole and do not crush, chew, or break it. Because prasugrel keeps your blood from clotting, prasugrel can also make it easier for you to bleed, even from a …

Brilinta dosages range from 60 mg to 90 mg by mouth twice daily. You can take Brilinta with or without food. And it can be crushed and mixed with water if you have trouble swallowing pills. Plavix is only taken once a day, at a dose of …

Keep Effient and all medicines out of the reach of children. General Information about Effient. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Effient for a condition for which it was not prescribed. Do not give your Effient to other people, even if they have the same symptoms you have.

The risk of bleeding is increased in patients receiving Effient who undergo CABG. If possible, Effient should be discontinued at least 7 days prior to CABG. Of the 437 patients who underwent CABG during TRITON-TIMI 38, the rates of CABG-related TIMI Major or Minor bleeding were 14.1% in the Effient group and 4.5% in the clopidogrel group.

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Effient is a P2Y 12 platelet inhibitor indicated for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with percutaneous coronary …

Headache, nausea, nosebleed, and stomach upset may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit …

Giving crushed prasugrel (Effient) to patients with ST-segment elevation myocardial infarction ... the investigator-initiated COMPARE CRUSH trial randomly allocated 727 STEMI patients (mean age ...

• Effient is used to lower your chance of having a heart attack or other serious problems with your heart or blood vessels. But, Effient can cause bleeding, which can be serious, and sometimes lead to death. You should not start to take Effient if it is likely that you will have heart bypass surgery (coronary artery bypass graft surgery or

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The goal of the trial was to assess the efficacy of prehospital crushed vs. integral prasugrel among ST-segment elevation myocardial infarction (STEMI) patients being …

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Effient can cause serious side effects, including: See "What is the most important information I should know about Effient?" A blood clotting problem called thrombotic thrombocytopenic purpura (TTP). TTP can happen with Effient, sometimes after a short time (less than 2 weeks). TTP is a blood clotting problem where blood clots form in blood ...

In STEMI patients undergoing PPCI, crushed prasugrel leads to faster drug absorption, and consequently, more prompt and potent antiplatelet effects compared with whole tablet ingestion. (Pharmacological Effects of Crushing Prasugrel in …

WARNING: BLEEDING RISK See full prescribing information for complete boxed warning. Effient can cause significant, sometimes fatal, bleeding (5.1, 5.2, 6.1).Do not use Effient in patients with active pathological bleeding or a history of transient ischemic attack or stroke (4.1, 4.2).In patients ≥75 years of age, Effient is generally not recommended, except in high-risk …

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Extended-release tablets may be scored or divided; however, do not crush or chew, swallow whole. Report any shortness of breath or facial swelling immediately to your doctor. Also, talk to your doctor if you develop a very slow heartbeat or …